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CPT 45380 — Colonoscopy and biopsy

CPT code 45380 (Colonoscopy and biopsy) carries 3.47 work RVUs under the CMS 2026 Medicare Physician Fee Schedule. Total RVUs are 14.37 in a non-facility setting and 5.32 in a facility setting, which at the 2026 conversion factor of $33.40 works out to $479.97 and $177.69 respectively.

3.47
Work RVU
14.37
Total RVU (non-facility)
$479.97
Medicare, non-facility
$177.69
Medicare, facility
Calculate your total wRVUs →

RVU breakdown for CPT 45380

ComponentRVUsWhat it covers
Work RVU3.47Physician time, skill, effort, and stress.
Practice expense RVU (non-facility)10.48Office overhead, staff, supplies.
Practice expense RVU (facility)1.43Overhead when performed in a hospital.
Malpractice RVU0.42Professional liability cost.
Total RVU (non-facility)14.37Work + non-facility PE + malpractice.
Total RVU (facility)5.32Work + facility PE + malpractice.

How Medicare payment is calculated

Medicare multiplies total RVUs by the annual conversion factor. For CPT 45380 in 2026:

SettingTotal RVUConversion factorNational payment
Non-facility14.37$33.40$479.97
Facility5.32$33.40$177.69

These are national amounts. Actual payment is adjusted by the Geographic Practice Cost Index for your locality — check yours with the GPCI lookup.

Billing rules for CPT 45380

Global period
0-day global — no pre- or post-operative period included.
Multiple procedure reduction
Subject to the multiple-endoscopy payment rule.
Bilateral surgery
Bilateral adjustment does not apply.
Assistant surgeon
Not permitted.
Co-surgeon
Not permitted unless documentation supports medical necessity.
Team surgery
Not permitted unless documentation supports medical necessity.

Related codes

Codes in the same CMS family, with their work RVU values.

45378 · 3.18 wRVU45379 · 4.17 wRVU45381 · 3.47 wRVU45382 · 4.54 wRVU45384 · 3.97 wRVU45385 · 4.46 wRVU45386 · 3.68 wRVU45388 · 4.76 wRVU

Questions about CPT 45380

How many work RVUs is CPT 45380?

CPT 45380 is assigned 3.47 work RVUs in the CMS 2026 Medicare Physician Fee Schedule.

What does Medicare pay for CPT 45380?

At the 2026 national conversion factor of $33.40, CPT 45380 pays approximately $479.97 in a non-facility setting and $177.69 in a facility setting before geographic adjustment.

What is the global period for CPT 45380?

0-day global — no pre- or post-operative period included.

RVU values reflect the CMS 2026 Medicare Physician Fee Schedule (conversion factor $33.40). Payment figures are national and unadjusted for geography. Verify against the official fee schedule before using for billing.